Stony Brook University · BiochemistryLuk Lab
Edward E Luk · Stony Brook, New York
Research Focus
Dr. Edward E Luk's lab at Stony Brook University focuses on understanding unique structures of chromatin, which are crucial for regulating gene expression and cellular processes. By studying specific histone variants and their roles in transcription and chromatin formation, the lab aims to uncover how these structures impact cellular behavior and may be linked to diseases like cancer. The research involves advanced biochemical techniques and models to explore these processes at a molecular level.
chromatingene expressiontranscriptionhistone variantsbiochemical techniquesgenomic researchtelomeresnucleosomesstructural biology
Research Aims
5AIM 01Investigate how histone variant H2A.Z targets specific genomic sites.
AIM 02Examine the role of R-octasomes in telomeric gene silencing.
AIM 03Explore the interplay between histone modifications and transcription.
AIM 04Develop methodologies to assess the function of variant chromatin structures.
AIM 05Understand the biophysical properties of chromatin and its role in gene regulation.
Skills the Lab Values
PCRbiochemical assayscell culturegenome editingcryo-electron microscopyin vitro transcription assaysgenetic analysishigh-throughput sequencingbioinformatics
Output against the department
Publications36bottom 3% of dept.388th of 402
this lab
most publishedleast published
Citations2.4kbottom 9% of dept.365th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.