Baylor College of Medicine · GeneticsSedlazeck Lab
Fritz J Sedlazeck · Houston, Texas
Research Focus
Dr. Fritz J. Sedlazeck's lab at Baylor College of Medicine focuses on improving the understanding of complex regions in the human genome, particularly those that impact cardiovascular disease risk. The lab develops innovative graph genome methods to analyze medically relevant genes, which will help identify genetic variants associated with diseases. Their work utilizes extensive genomic data and aims to make genetic analysis accessible to a broader community, ultimately contributing to better diagnostics and therapies for various conditions.
genome sequencinggenetic variantscardiovascular diseasegraph genomelong-read sequencinggenomic data
Research Aims
4AIM 01Develop a graph genome method for analyzing complex regions of the human genome.
AIM 02Identify and characterize genetic variants linked to cardiovascular disease.
AIM 03Utilize large genomic datasets to enhance variant detection capabilities.
AIM 04Collaborate with researchers to validate pathogenicity of newly discovered variants.
Skills the Lab Values
graph genome constructionlong-read DNA sequencingbioinformaticsgenetic data analysisvariant validationphenotypic assessmentdata benchmarkinggenome annotation
Output against the department
Publications381top 20% of dept.52nd of 259
this lab
most publishedleast published
Citations30ktop 19% of dept.50th of 259
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.