University of Pennsylvania · BiologyJin Lab
Chengcheng Jin · Philadelphia, Pennsylvania
Research Focus
Dr. Chengcheng Jin's lab focuses on understanding how neutrophils, a type of immune cell, behave in the context of cancer. They investigate how these cells change their function in the tumor microenvironment and how to selectively target the cancer-promoting activities of neutrophils while preserving their protective roles. Through advanced techniques, the lab aims to uncover new targets for cancer therapies that can effectively modulate neutrophil function without compromising immune health.
neutrophilscancer immunotherapytumor microenvironmentepigenetic reprogrammingtranscriptional regulationgenetically engineered mouse modelsimmune responsetumor progressionspatial transcriptomics
Research Aims
5AIM 01Investigate neutrophil heterogeneity in the tumor microenvironment.
AIM 02Identify specific factors that reprogram neutrophils to discrete functional subsets.
AIM 03Analyze transcriptional and epigenetic changes in tumor-associated neutrophils.
AIM 04Utilize novel genetic perturbation tools to explore neutrophil functions.
AIM 05Develop targets for cancer therapy that modulate neutrophil activity.
Skills the Lab Values
single-cell RNA sequencingFACSgenetic manipulation in micechromatin profilingspatial transcriptomicsphenotypic analysiscell culture techniquesbioinformaticsimmunohistochemistry
Output against the department
Publications58bottom 14% of dept.881st of 1,033
this lab
most publishedleast published
Citations8.7ktop 44% of dept.451st of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.