UTHThe University of Texas Health Science Center at Houston · Neuroscience
The PRMT NeuroLab
Hung Wen (Kevin) Lin · Houston, Texas
Research Focus
Dr. Hung Wen (Kevin) Lin's lab focuses on understanding the roles of protein arginine methyltransferases (PRMTs) in Alzheimer's disease and Alzheimer's-related vascular cognitive impairment. The lab investigates how modifications in PRMTs influence brain metabolism, blood flow, and cognitive functions, particularly in female mouse models. They are also exploring innovative treatments using photobiomodulation, a non-invasive therapy, to mitigate cognitive decline associated with these conditions.
Alzheimer's Diseasephotobiomodulationprotein arginine methyltransferaseneurovascular couplingcognitive impairmentvascular dementiamouse modelstherapeutic strategiesmicrovessel perfusion
Research Aims
5AIM 01Investigate the role of protein arginine methyltransferase 4 in Alzheimer's disease
AIM 02Evaluate the impact of photobiomodulation on cognitive functions in mouse models
AIM 03Explore sex differences in the progression of Alzheimer's disease
AIM 04Assess neurovascular coupling and blood-brain barrier integrity in models of neurodegeneration
AIM 05Develop therapeutic strategies to enhance brain health in aging populations.
Skills the Lab Values
two-photon laser scanning microscopyphotobiomodulationanimal handling (mice)neuroscience techniquesdata analysis in neurosciencemolecular biology techniquesimmunohistochemistrybehavioral testing in miceexperimental design
Output against the department
Publications54bottom 13% of dept.585th of 671
this lab
most publishedleast published
Citations1.3kbottom 7% of dept.623rd of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.