University of California-Davis · PharmacologyNavedo Lab
Manuel F Navedo · Davis, California
Research Focus
Professor Manuel F. Navedo's lab at UC Davis focuses on understanding the mechanisms behind vascular smooth muscle dysfunction related to diabetes and heart failure. The research particularly investigates how pressure influences calcium channels in blood vessels and how this process can affect blood flow and blood pressure in health and disease. By exploring these mechanisms, the lab aims to identify new potential treatments for vascular complications associated with lifestyle-related diseases.
vascular smooth musclediabetesheart failurecalcium channelsblood pressure regulationmyogenic responsecell signalingvascular complicationspressure modulation
Research Aims
5AIM 01Investigate the role of Panx1 in hyperglycemia signaling in vascular smooth muscle.
AIM 02Determine the impact of Panx1 on vascular smooth muscle dysfunction during diabetes and heart failure.
AIM 03Explore how pressure affects the spatiotemporal properties of CaV1.2 channels in vascular smooth muscle.
AIM 04Examine the involvement of kinase activity in pressure regulation of CaV1.2 channels.
AIM 05Assess how pressure modulation of CaV1.2 dynamics is altered in disease states.
Skills the Lab Values
cell culturecalcium imagingelectrophysiologyWestern blottingmouse modelsPCRdata analysisvascular reactivity assaystissue staining
Output against the department
Publications181top 50% of dept.228th of 462
this lab
most publishedleast published
Citations4.6kbottom 34% of dept.304th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.