Tulane University of Louisiana · BiologyAging and Retinal Health Laboratory
Shusheng Wang · New Orleans, Louisiana
Research Focus
Dr. Shusheng Wang's lab at Tulane University focuses on studying the effects of aging and cigarette smoke on the retinal pigment epithelium (RPE) and its role in age-related macular degeneration (AMD). They investigate how mitochondrial dysfunction induced by these factors can lead to different RPE phenotypes, potentially contributing to the disease. The lab aims to understand the mechanisms driving this heterogeneity and to identify potential therapeutic targets for treating dry AMD.
age-related macular degenerationretinal pigment epitheliummitochondrial dysfunctioncigarette smokecellular senescence
Research Aims
3AIM 01Investigate how mitochondrial dysfunction from aging impacts RPE heterogeneity and EMT.
AIM 02Determine the role of cigarette smoke in exacerbating mitochondrial dysfunction and RPE phenotype variations.
AIM 03Explore the link between RPE senescence and mitochondrial dysfunction in the context of AMD.
Skills the Lab Values
cell cultureanimal modelsmolecular signaling analysisROS measurementepithelial-mesenchymal transition assays
Output against the department
Publications162top 41% of dept.424th of 1,033
this lab
most publishedleast published
Citations10ktop 36% of dept.371st of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.