Oregon State University · PharmacologySahay Lab
Gaurav Sahay · Corvallis, Oregon
Research Focus
Dr. Gaurav Sahay's lab focuses on developing innovative gene therapy solutions for two major health issues: cystic fibrosis and inherited retinal degenerations. The lab works on creating advanced nanoparticle systems to deliver optimized mRNA and gene editing tools directly to targeted cells in the lungs and retina. By leveraging cutting-edge technologies such as microfluidics and AI-assisted design, the research aims to improve treatment effectiveness while minimizing invasiveness and side effects.
cystic fibrosisgene therapynanoparticlesRetinal degenerationmRNA deliverygene editingmicrofluidicsAI optimization
Research Aims
5AIM 01Develop inhalable nanoparticles containing AI-optimized CFTR mRNA for cystic fibrosis treatment.
AIM 02Optimize gene editing platforms to target inherited retinal degenerations.
AIM 03Utilize novel nebulizer technology for effective mRNA delivery.
AIM 04Employ phage display to identify peptide targets for retinal delivery.
AIM 05Evaluate efficacy and safety of treatments in preclinical models.
Skills the Lab Values
PCRcell culturemouse modelslipid nanoparticle formulationphage displayin vivo imaginggene editing techniquesnanoparticle characterizationmRNA synthesismicrofluidic device fabrication
Output against the department
Publications122bottom 35% of dept.300th of 462
this lab
most publishedleast published
Citations15ktop 26% of dept.119th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.