University of Florida · PharmacologyMclaughlin Neuropharmacology Lab
Jay P. Mclaughlin · Gainesville, Florida
Research Focus
Dr. Jay P. Mclaughlin's research focuses on understanding how opioids like morphine interact with HIV proteins to affect brain health and behavior. His lab studies the impacts of these substances on brain function and emotional well-being, particularly in people living with both HIV and opioid use disorder. By exploring treatments like dimethylfumarate, which may protect brain function, his work aims to develop better interventions for vulnerable patients.
opioid use disorderHIVmorphinebrain functiondimethylfumarateneurocognitionmitochondrial functionBDNFbehavioral healthmental health
Research Aims
5AIM 01Investigate how morphine and HIV Tat protein affect behavior in animal models.
AIM 02Examine the role of BDNF in brain function and emotional well-being.
AIM 03Evaluate the protective effects of dimethylfumarate on mitochondrial function.
AIM 04Characterize the interactions between opioids and HIV proteins at a molecular level.
AIM 05Develop insights into treatment strategies for opioid use disorder in HIV patients.
Skills the Lab Values
animal modelsbehavioral assaysmagnetic resonance spectroscopycell cultureWestern blot analysisRNA extractionPCRdata analysisimmunohistochemistrydrug treatment protocols
Output against the department
Publications165bottom 46% of dept.250th of 462
this lab
most publishedleast published
Citations6.1kbottom 43% of dept.262nd of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.