University of California-San Francisco · BiochemistryNarlikar Chromatin Lab
Geeta J Narlikar · San Francisco, California
Research Focus
Dr. Geeta J Narlikar's lab at UCSF focuses on understanding how chromatin, the material that makes up our DNA, is regulated in cells. They study both active and repressed states of chromatin, which are crucial for maintaining cellular identity and function. By investigating the mechanisms of chromatin remodeling and phase separation, the lab aims to discover how these processes relate to development and diseases, particularly cancer.
chromatin remodelingheterochromatineuchromatinphase separationbiophysicscell differentiationnucleosomesATP-dependent mechanismstherapeutic intervention
Research Aims
3AIM 01Investigate the regulatory mechanisms of chromatin remodelers.
AIM 02Determine the impact of nucleosome-scale actions on broader chromatin organization.
AIM 03Explore the role of phase separation in the regulation of heterochromatin.
Skills the Lab Values
biophysical techniqueschromatin immunoprecipitationcell culturegel electrophoresismicroscopyRNA sequencingWestern blottingprotein purificationdata analysis in Python
Output against the department
Publications145bottom 41% of dept.239th of 402
this lab
most publishedleast published
Citations13ktop 38% of dept.151st of 402
this lab
most citedleast cited
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