University of Texas Southwestern Medical Center · NeuroscienceBiomolecular Condensates and RNA Dynamics Lab
David Winland Sanders · Dallas, Texas
Research Focus
Dr. David Winland Sanders' lab at UT Southwestern focuses on understanding how RNA-rich structures in cells, known as biomolecular condensates, influence RNA homeostasis and their roles in diseases like ALS. By exploring the dynamics of these membraneless compartments, the lab aims to uncover the mechanisms behind neuromuscular diseases caused by protein aggregates. The research combines insights from biophysics and cell biology to identify potential therapeutic targets for treatment.
RNA homeostasisbiomolecular condensatesneuromuscular diseasesprotein aggregationtherapeutic intervention
Research Aims
5AIM 01Investigate the role of RNA-rich biomolecular condensates in RNA homeostasis.
AIM 02Explore how condensate dysfunction contributes to neuromuscular diseases.
AIM 03Develop tools to quantify protein aggregate levels in cells.
AIM 04Test the hypothesis that condensates can solubilize and prevent RNA entanglement.
AIM 05Identify new therapeutic targets for intervention in diseases with RNA-binding protein aggregates.
Skills the Lab Values
cell culturebiochemical assaysimaging techniquesbiophysics methodsmolecular cloning
Output against the department
Publications44bottom 9% of dept.611th of 671
this lab
most publishedleast published
Citations6.0kbottom 42% of dept.388th of 671
this lab
most citedleast cited
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