WMCWeill Medical College of Cornell University · Neuroscience
Immune AlzLab
Subhash C Sinha · New York, New York
Research Focus
Dr. Subhash C. Sinha's lab focuses on discovering new treatments for Alzheimer's disease by targeting the immune system's response to tau pathology, a key factor in memory loss. The research aims to develop small molecule inhibitors of a protein called cGAS, which plays a role in neuroinflammation associated with Alzheimer's. By investigating these inhibitors, the lab hopes to identify therapeutic strategies that can reduce cognitive deficits in Alzheimer's disease.
Alzheimer's diseasecGASneuroinflammationtau pathologyimmune responsesmall molecule inhibitorsdrug developmentcognitive impairmentmicrogliosis
Research Aims
3AIM 01Develop lead human cGAS inhibitors to modulate the cGAS-STING pathway.
AIM 02Optimize analogs of a potent cGAS inhibitor for enhanced efficacy.
AIM 03Establish pharmacokinetics and efficacy of cGAS inhibitors in tauopathy models.
Skills the Lab Values
cell-based assayssmall molecule synthesisanimal models (mice)high-throughput screeningin vivo pharmacokineticsdrug designbiochemical assaysmolecular dockingstem cell-derived models
Output against the department
Publications222top 33% of dept.222nd of 671
this lab
most publishedleast published
Citations4.0kbottom 30% of dept.467th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.