Wayne State University · PhysiologySperm Development and Fertility Lab
Zhibing Zhang · Detroit, Michigan
Research Focus
Dr. Zhibing Zhang's lab at Wayne State University focuses on understanding the development and functioning of sperm cells, with an emphasis on the mechanisms involved in spermiogenesis and fertilization. They investigate how specific proteins and complexes, like the MEIG1 complex and the IFT25/IFT27 complex, contribute to the formation of sperm flagella and the remodeling of chromatin, which is crucial for normal reproductive processes.
spermiogenesisfertilizationintraflagellar transportsperm formationchromatin remodelingMEIG1 complexIFT25IFT27male fertilityembryogenesis
Research Aims
5AIM 01Explore the roles of the MEIG1 complex in sperm flagella formation.
AIM 02Investigate the transport mechanisms involved in spermatid development.
AIM 03Examine chromatin remodeling processes during spermiogenesis.
AIM 04Analyze the role of IFT in sperm accessory structure assembly.
AIM 05Develop in vivo systems to visualize protein dynamics in germ cells.
Skills the Lab Values
cell culturemouse modelsgene knockout techniquesimmunofluorescenceprotein extractionWestern blottinglive cell imagingCRISPR genome editingbiochemical assaysmicroscopy
Output against the department
Publications677top 2% of dept.6th of 286
this lab
most publishedleast published
Citations16ktop 18% of dept.51st of 286
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.