University of Minnesota-Twin Cities · EngineeringZasadzinski Surfactant Lab
Joseph Anthony Zasadzinski · Minneapolis, Minnesota
Research Focus
Joseph Anthony Zasadzinski's lab at the University of Minnesota focuses on understanding lung surfactants and their role in acute respiratory distress syndrome (ARDS). They investigate how lysolipids affect the stability of lung surfactant monolayers, which is critical for maintaining healthy lung function. The lab aims to develop effective therapies for ARDS, particularly relevant in the context of COVID-19, by exploring ways to stabilize lung surfactants and prevent lung collapse during respiration.
ARDSlung surfactantslysolipidsmonolayer stabilityCOVID-19
Research Aims
5AIM 01Characterize how lysolipid micelles solubilize lung surfactant.
AIM 02Examine the coupling between monolayer morphology and interfacial curvature.
AIM 03Determine the effects of different lysolipids on minimum surface tension.
AIM 04Develop synthetic lung surfactants that resist lysolipid interference.
AIM 05Provide new methods for stabilizing lung function in ARDS patients.
Skills the Lab Values
dynamic light scatteringmicrotensiometerliposome preparationinterfacial tension measurementexperimental designbiomechanicsdata analysistheoretical modelingprotein adsorption techniques
Output against the department
Publications266top 33% of dept.91st of 278
this lab
most publishedleast published
Citations14ktop 27% of dept.76th of 278
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.