Augusta University · BiochemistryBladder Cancer Therapeutics Lab
Vinata B Lokeshwar · Augusta, Georgia
Research Focus
Dr. Vinata B Lokeshwar's lab at Augusta University focuses on improving treatments for high-risk bladder cancer. Their research investigates how to overcome resistance to chemotherapy, specifically the drug Gemcitabine, by targeting a newly identified enzyme called Chase. The lab aims to develop combination therapies that enhance the effectiveness of existing treatments and to identify biomarkers that help predict patient responses to these therapies.
bladder cancerchemotherapyGemcitabinebiomarkersdrug resistanceenzymesimmunotherapyneoadjuvant therapypatient-derived models
Research Aims
3AIM 01Evaluate two evidence-based Gem combinations to improve outcomes for high-risk bladder cancer patients.
AIM 02Investigate the molecular mechanisms of Chase-induced Gem resistance.
AIM 03Develop biomarkers related to Chase for predicting treatment response.
Skills the Lab Values
cell culturebladder tumor modelsdrug combination testingbiomarker analysisxenograft modelsmolecular signaling pathway analysistissue processinganimal modelsimmunohistochemistry
Output against the department
Publications168bottom 48% of dept.209th of 402
this lab
most publishedleast published
Citations4.1kbottom 22% of dept.313th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.