University of Illinois Chicago · PharmacologyAntimalarial Drug Development Lab
Paul R Carlier · Chicago, Illinois
Research Focus
Dr. Paul R Carlier's lab at the University of Illinois at Chicago focuses on developing new drugs to fight malaria, a disease that affects millions worldwide. The lab is optimizing new antimalarial compounds that can target different life stages of the malaria parasite, with the goal of overcoming drug resistance. Students in the lab will learn important laboratory techniques while helping to create treatments that could save lives.
antimalarialsPlasmodiumdrug resistancelife cycle stagespharmacokinetics
Research Aims
5AIM 01Develop new antimalarials with novel mechanisms of action.
AIM 02Optimize lead compounds for targeting multiple malaria life stages.
AIM 03Study the pharmacokinetics of new drug candidates.
AIM 04Identify mechanisms of resistance in malaria parasites.
AIM 05Create structure-activity relationships for effective drug development.
Skills the Lab Values
synthetic chemistrystructure-activity relationship (SAR) analysisdrug formulationbiological assayscell cultureproteomics techniquesvirtual ligand screening (VLS)animal models (mice)chemoproteomicspharmacological testing
Output against the department
Publications229top 36% of dept.166th of 462
this lab
most publishedleast published
Citations5.0kbottom 37% of dept.292nd of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.