University of Kentucky · PhysiologyLipoprotein and Metabolic Health Lab
Scott M Gordon · Lexington, Kentucky
Research Focus
Dr. Scott M. Gordon's lab at the University of Kentucky studies the interactions between lipoproteins, which transport fats in the bloodstream, and various proteins that influence cardiovascular health. One major focus is understanding how lipoproteins can suppress inflammation related to atherosclerosis, a condition characterized by artery plaque buildup. The lab also investigates the gene DENND5B, which plays a vital role in the absorption of dietary fats and may affect overall metabolic health. Through their research, they aim to uncover new mechanisms that could inform strategies for preventing heart disease.
lipoproteinsatherosclerosisDENND5Bdietary lipid absorptionvascular inflammationprotease inhibitorsmetabolic healthtriacylglyceridescardiovascular diseasein vivo mouse models
Research Aims
3AIM 01Investigate the structural interactions between lipoproteins and protease inhibitors to understand their roles in vascular inflammation.
AIM 02Explore the function of DENND5B in the secretion of dietary lipids from intestinal cells and its impact on metabolic health.
AIM 03Determine how lipoprotein-associated protease inhibitors influence cardiovascular disease outcomes through in vivo studies.
Skills the Lab Values
mass spectrometryin vitro functional assaysmouse modelscross-linking mass spectrometryRNA sequencingprotein interaction analysislipid profilingdata analysis in biologycell culture techniquesgenetic manipulation
Output against the department
Publications46bottom 6% of dept.269th of 286
this lab
most publishedleast published
Citations2.9kbottom 22% of dept.224th of 286
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.