UTMThe University of Texas MD Anderson Cancer Center · Genetics
RESToration Lab
Sadhan Majumder · Houston, Texas
Research Focus
Dr. Sadhan Majumder's lab focuses on understanding chronic neuropathic pain and how to improve opioid treatment safety. They investigate the role of a protein called REST in regulating opioid receptors in nerve cells, which can affect how the body responds to pain. The research aims to develop new strategies to enhance pain relief while minimizing the risk of addiction and tolerance to opioids.
chronic painopioid receptorsRESTnerve injurypain mechanisms
Research Aims
4AIM 01Investigate how REST regulates opioid receptor expression in dorsal root ganglion neurons.
AIM 02Explore the impact of peripheral nerve injury on opioid analgesia and REST activity.
AIM 03Determine the genetic mechanisms underlying opioid-induced hyperalgesia and analgesic tolerance.
AIM 04Develop new strategies to enhance opioid efficacy and reduce consumption in pain management.
Skills the Lab Values
genetic mouse modelschromatin analysisreal-time PCRimmunohistochemistryRNA sequencing
Output against the department
Publications60bottom 13% of dept.225th of 259
this lab
most publishedleast published
Citations4.8kbottom 25% of dept.193rd of 259
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.