North Carolina State University at Raleigh · BiologyMacaque HIV Adaptation Laboratory
Amit Sharma · Raleigh, North Carolina
Research Focus
Dr. Amit Sharma's research lab focuses on understanding how HIV-1 adapts to macaques, as these animals are used to model HIV infection for vaccine studies. By studying chimeric simian-human immunodeficiency viruses (SHIVs) and the immune responses in macaques, the lab aims to determine why existing models fail to replicate efficiently and how this can be improved. The ultimate goal is to enhance our understanding of HIV infection and help design better vaccine strategies.
HIVSHIVmacaquesviral adaptationhost factors
Research Aims
3AIM 01Characterize the adaptive changes in SHIVs that increase replication in macaques.
AIM 02Determine the role of specific Env glycans in SHIV infection.
AIM 03Evaluate the contribution of macaque IFITM proteins in restricting SHIV infection.
Skills the Lab Values
molecular cloningcell culturevirologyin vivo experimentationimmunological assays
Output against the department
Publications183top 36% of dept.368th of 1,033
this lab
most publishedleast published
Citations11ktop 33% of dept.342nd of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.