RUThe Rockefeller University · Biology
LINE-1 Neurogenetics Lab
John Lacava · New York, New York
Research Focus
Dr. John Lacava's research lab focuses on understanding the role of LINE-1 retrotransposons in neurodegenerative diseases like Alzheimer's Disease and related dementias. By investigating how these genetic elements contribute to cellular aging and inflammation, the lab aims to uncover potential mechanisms behind the onset of these diseases. Through various experimental approaches, including examining biological samples from patients and cell cultures, the lab seeks to clarify the relationship between LINE-1 and cellular senescence, ultimately hoping to inform strategies for better understanding and treating these conditions.
Alzheimer's DiseaseAD-related dementiascellular senescenceLINE-1 retrotransposonsinflammationmolecular geneticsprotein interactionsneurodegenerative disordersaging
Research Aims
4AIM 01Profile LINE-1 ORF1 protein expression in CSF and brain tissues from AD patients.
AIM 02Analyze protein-protein and protein-RNA interactions involving LINE-1 in biological samples.
AIM 03Investigate the mechanisms of action of LINE-1 in cellular senescence.
AIM 04Examine the role of LINE-1 in neurodegeneration and cognitive decline.
Skills the Lab Values
cell culture techniquestargeted mass spectrometryimmunoprecipitationRNA sequencingbioinformaticsmolecular geneticscellular assaysbiological sample analysisdata analysis in biological research
Output against the department
Publications219top 28% of dept.294th of 1,033
this lab
most publishedleast published
Citations3.8kbottom 29% of dept.734th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.