EUEmory University · Pharmacology
Breast Cancer Immune Evasion Lab
Yong Wan · Atlanta, Georgia
Research Focus
Dr. Yong Wan's research lab at Emory University focuses on understanding how certain proteins involved in breast cancer, specifically B7-H4 and CD73, can evade the immune system and resist treatment. By studying how these proteins are modified and regulated, the lab aims to uncover new strategies to improve treatment outcomes, especially in aggressive types of breast cancer like triple-negative breast cancer (TNBC). Their work could lead to the development of novel therapies that enhance the body's ability to fight cancer.
breast cancertriple-negative breast cancerimmune evasionprotein modificationubiquitinationglycosylationchemotherapytumor microenvironment
Research Aims
3AIM 01Investigate how glycosylation and ubiquitination of B7-H4 influence its role in tumor immunity.
AIM 02Explore the significance of TRIM21 in regulating CD73 to enhance anti-cancer immune responses.
AIM 03Evaluate the therapeutic potential of targeting B7-H4 and CD73 modifications in preclinical models.
Skills the Lab Values
cell cultureWestern blotflow cytometrymouse modelsprotein purificationimmunohistochemistryRNA extractionreal-time PCRT cell assays
Output against the department
Publications342top 21% of dept.96th of 462
this lab
most publishedleast published
Citations4.6kbottom 35% of dept.302nd of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.