Harvard University · Microbiology & ImmunologyAbraham Virology Lab
Jonathan Abraham · Cambridge, Massachusetts
Research Focus
Dr. Jonathan Abraham's lab at Harvard Medical School studies alphaviruses, which are mosquito-borne viruses that can lead to severe brain infections. The lab focuses on understanding the cellular receptors these viruses use to infect brain cells and exploring potential therapeutic approaches to prevent infections. By using advanced techniques like cryo-electron microscopy, the lab aims to visualize virus-receptor interactions and develop strategies to combat these dangerous pathogens.
alphavirusviral encephalitisreceptor biologyantiviral developmentneuroinflammation
Research Aims
3AIM 01Identify and characterize cellular receptors for eastern equine encephalitis virus.
AIM 02Evaluate the role of western equine encephalitis virus receptors in human brain cell infection.
AIM 03Determine the structure of virus-like particles bound to alphavirus receptors.
Skills the Lab Values
cryoelectron microscopycell culturein vitro binding assaysbioinformaticsviral pathogenesis models
Output against the department
Publications67bottom 19% of dept.393rd of 486
this lab
most publishedleast published
Citations3.3kbottom 25% of dept.366th of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.