University of North Texas Health Science Center · Microbiology & ImmunologyXiang Virology Lab
Yan Xiang · Fort Worth, Texas
Research Focus
Dr. Yan Xiang's research lab focuses on understanding how certain viruses, specifically poxviruses like monkeypox, interact with their hosts. The lab investigates the cellular defense mechanisms that identify and restrict viral infections and how viruses adapt to overcome these defenses. By studying these interactions, the lab aims to uncover new antiviral strategies and contribute to public health efforts against viral outbreaks.
poxvirusmonkeypoxhost rangeviral infectionantiviral mechanismstranslational controltRNAcellular stresshost-pathogen interactions
Research Aims
3AIM 01Define the tRNA specificity of SAMD9/9L and its impact on poxvirus replication.
AIM 02Investigate how poxvirus infection activates SAMD9.
AIM 03Explore the molecular interactions between SAMD9/9L and poxvirus inhibitors.
Skills the Lab Values
PCRcell culturemolecular cloningWestern blotRNA sequencingbioinformaticsCRISPRprotein purificationimmunofluorescence microscopy
Output against the department
Publications343top 12% of dept.59th of 486
this lab
most publishedleast published
Citations9.5ktop 38% of dept.187th of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.