Thomas Jefferson University · BiologyMenko Immunology Lab
A. Sue Menko · Philadelphia, Pennsylvania
Research Focus
Dr. A. Sue Menko's research lab at Thomas Jefferson University focuses on understanding how the immune system interacts with the eye, particularly in maintaining health after injuries like corneal wounds. The lab studies special immune cells associated with the lens of the eye to learn how they can either help restore balance or lead to problems such as cataracts and glaucoma. Their work is crucial for developing new treatments for eye diseases caused by inflammation.
anterior segmentimmune responseuveitiscorneal injurycataractimmune modulationocular pathologyhomeostasisinflammationantigen presentation
Research Aims
3AIM 01Trace the lineage of lens resident immune cells and those recruited during corneal injury.
AIM 02Analyze the immunomodulatory properties of lens capsule associated immune cells (LC-AICs) post-injury.
AIM 03Investigate mechanisms of LC-AIC infiltration into the lens and their role in cataract development.
Skills the Lab Values
lineage tracingimmunofluorescencecell cultureanimal modelsmicroscopybiological assaysflow cytometryproteomicsmolecular profilingWestern blot
Output against the department
Publications182top 36% of dept.372nd of 1,033
this lab
most publishedleast published
Citations11ktop 33% of dept.346th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.