MCWMedical College of Wisconsin · Physiology
OMeara Lab
Caitlin C O'Meara · Milwaukee, Wisconsin
Research Focus
Caitlin O'Meara's lab focuses on understanding how heart cells, known as cardiomyocytes, can regenerate and repair after injury. By studying specific proteins in both zebrafish and mice, the lab aims to uncover mechanisms that allow heart cells to heal and function properly, especially in cases of heart failure. This research could lead to new regenerative therapies for patients with heart conditions.
cardiac regenerationcardiomyocytesLlgl1Shroom3heart repairHippo-Yap signalingzebrafish modeladult heart functioncellular architecturetherapeutic modulation
Research Aims
5AIM 01Identify how Llgl1 and Shroom3 influence cardiomyocyte proliferation after heart injury.
AIM 02Investigate the role of junctional and cytoskeletal proteins in cardiac regeneration.
AIM 03Explore the interaction of these proteins with Hippo-Yap signaling pathways.
AIM 04Use zebrafish mutants to study cardiac morphogenesis.
AIM 05Assess the impact of protein modulation on heart function in adult mice.
Skills the Lab Values
zebrafish manipulationtransgenic mouse modelscell culture techniquesimmunofluorescence microscopyWestern blottinggene knockout techniquesflow cytometrymolecular cloninghistologyprotein interaction assays
Output against the department
Publications73bottom 16% of dept.241st of 286
this lab
most publishedleast published
Citations1.4kbottom 6% of dept.268th of 286
this lab
most citedleast cited
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