University of Pennsylvania · BiochemistryApolipoprotein E Structural Lab
Gregory Bowman · Philadelphia, Pennsylvania
Research Focus
Dr. Gregory Bowman's lab at the University of Pennsylvania focuses on understanding the structural role of the apolipoprotein E (ApoE) protein in Alzheimer's disease. By using advanced computer simulations and experimental techniques, the lab aims to uncover the differences between harmful and protective isoforms of ApoE, which could lead to the development of new therapies for Alzheimer's. The research is crucial given the increasing prevalence of Alzheimer's disease as the population ages.
Alzheimer's diseaseApoEneurotoxicityprotein structuredrug design
Research Aims
5AIM 01Investigate the structural determinants of ApoE-induced neurotoxicity.
AIM 02Develop new algorithms to analyze the conformational heterogeneity of ApoE.
AIM 03Characterize the allosteric mechanisms that link different regions of ApoE.
AIM 04Test computational predictions through experimental methods.
AIM 05Design 'structure correctors' to stabilize non-toxic ApoE conformations.
Skills the Lab Values
atomistic modelingMarkov state modelssingle molecule Förster resonance energy transfer (smFRET)adaptive sampling algorithmsstructural biology techniques
Output against the department
Publications214top 37% of dept.147th of 402
this lab
most publishedleast published
Citations12ktop 41% of dept.166th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.