UMCUniversity of Massachusetts Chan Medical School · Microbiology & Immunology
Sassetti Lab
Christopher M Sassetti · Worcester, Massachusetts
Research Focus
Dr. Christopher Sassetti's lab focuses on understanding how genetic diversity among both humans and the tuberculosis bacterium affects disease outcomes. By using advanced models, including mice that mimic human genetic diversity, the lab studies how different genetic and environmental factors interact to influence tuberculosis infection. The goal is to identify pathways that impact disease progression and improve strategies for diagnosis and vaccination against tuberculosis.
tuberculosisgenetic diversitymouse modelsvaccinationpathway analysisdisease outcomesMycobacterium tuberculosisimmune responseclinical phenotypes
Research Aims
5AIM 01Investigate the genetic factors influencing tuberculosis disease outcomes.
AIM 02Examine the interactions between host genetics and bacterial diversity.
AIM 03Develop diagnostic strategies based on clinical phenotypes.
AIM 04Optimize vaccine development through identified pathways.
AIM 05Explore the effects of environmental factors on tuberculosis susceptibility.
Skills the Lab Values
mouse modelsgenetic sequencingimmunological assaysvaccination techniquespathogen culturegene editingdata analysisphenotype characterizationbiological modeling
Output against the department
Publications191top 34% of dept.163rd of 486
this lab
most publishedleast published
Citations19ktop 20% of dept.95th of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.