University of Southern California · Biomedical EngineeringCardiac Injury Research Lab
Megan Laura Mccain · Los Angeles, California
Research Focus
Dr. Megan Laura Mccain's lab at USC focuses on understanding heart injuries, particularly how oxygen levels affect the communication between different cell types in the heart after a heart attack. They use advanced technologies to create models that mimic heart conditions, enabling them to study how these interactions can lead to better treatments for patients recovering from heart attacks. Through their work, they hope to develop new therapies to improve heart health and outcomes.
myocardial infarctioncardiac tissue engineeringoxygen gradientcell communicationhypoxiafibroblastsmacrophagescardiomyocytes
Research Aims
3AIM 01Investigate the effects of hypoxic-normoxic crosstalk between cardiac fibroblasts and macrophages on their functional phenotypes.
AIM 02Analyze how cardiomyocyte-fibroblast-macrophage interactions influence cardiac tissue function after myocardial infarction.
AIM 03Establish spatial RNA sequencing techniques to study gene expression in engineered cardiac tissues under varied oxygen conditions.
Skills the Lab Values
microfluidic device fabricationcell cultureelectrophysiologyRNA sequencingproteomicsco-culture techniquesdata analysismolecular biology techniques
Output against the department
Publications91bottom 15% of dept.508th of 595
this lab
most publishedleast published
Citations5.2kbottom 39% of dept.360th of 595
this lab
most citedleast cited
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