Indiana University-Purdue University-Indianapolis · GeneticsColorectal Cancer Immunotherapy Lab
Xinna Zhang · Indianapolis, Indiana
Research Focus
Dr. Xinna Zhang's lab at Indiana University Indianapolis focuses on enhancing the immune response against colorectal cancer by improving how tumors present antigens to the immune system. The team investigates how herbal compounds can boost the effectiveness of cancer immunotherapies. They aim to develop innovative strategies to make colorectal tumors more recognizable to immune cells so that treatments can work better for patients.
colorectal cancerimmunotherapyantigen presentationimmune checkpoint blockadeT cell cytotoxicitynatural compoundsHERBAL MEDICINEimmunoproteasome
Research Aims
3AIM 01Identify the molecular mechanisms by which atractylenolide I enhances antigen processing in colorectal cancer cells.
AIM 02Evaluate the impact of atractylenolide I on immune cell infiltration and activity within tumors.
AIM 03Assess the therapeutic efficacy of atractylenolide I in combination with immune checkpoint blockade in cancer models.
Skills the Lab Values
cell culturemouse modelsflow cytometryWestern blotPCRbiological assaysdrug screeningbioinformaticsimmunology techniques
Output against the department
Publications210top 39% of dept.102nd of 259
this lab
most publishedleast published
Citations7.3kbottom 40% of dept.155th of 259
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.