University of Illinois Chicago · PharmacologyVascular Health Research Laboratory
Sang Ging Ong · Chicago, Illinois
Research Focus
Dr. Sang Ging Ong's lab focuses on understanding how cancer treatment, specifically sunitinib, affects the health of blood vessels. They study the regulation of protein production in endothelial cells, which are critical for maintaining vascular health. Through their research, they aim to uncover mechanisms that could reduce harmful side effects of cancer therapies, helping to improve patients' overall quality of life.
vascular dysfunctionsunitinibendothelial cellstranslational controlcardiovascular toxicityDNA damage repairdrug repurposingangiotensin-converting enzyme inhibitors
Research Aims
3AIM 01Investigate how sunitinib affects translation in endothelial cells.
AIM 02Define the role of SND1 in protecting endothelial cells from sunitinib toxicity.
AIM 03Validate the protective effects of ramipril on endothelial function during sunitinib treatment.
Skills the Lab Values
cell cultureWestern blotRNA analysisin vitro assaysbioinformaticsdrug screeningmolecular cloninggene expression profilinganimal modelsprotein interaction studies
Output against the department
Publications106bottom 28% of dept.333rd of 462
this lab
most publishedleast published
Citations6.8kbottom 48% of dept.241st of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.