UMCUniversity of Massachusetts Chan Medical School · Biology
The Apoptosis Dynamics Lab
Andreas Bergmann · Worcester, Massachusetts
Research Focus
Dr. Andreas Bergmann's lab at the University of Massachusetts Medical School researches how programmed cell death, or apoptosis, affects tissue health and regeneration. By studying the fruit fly Drosophila, the lab explores how dying cells can signal nearby cells to grow, potentially leading to new cancer treatments. Their work aims to understand the genetic and molecular mechanisms behind these processes, which can enhance our knowledge of diseases like cancer, where cell death and growth signaling are crucial.
apoptosisregenerative proliferationDrosophilacaspasetumor biologycell death mechanismsgenetic screeningreactive oxygen specieshemostasis
Research Aims
4AIM 01Investigate the regulation of caspase activity in apoptosis and regenerative responses.
AIM 02Identify the non-apoptotic roles of caspases in cellular mechanisms.
AIM 03Explore how reactive oxygen species are generated by caspases to promote cellular growth.
AIM 04Characterize the role of macrophages in response to apoptotic cells and their impact on tissue regeneration.
Skills the Lab Values
genetic screeningDrosophila geneticsmolecular cloningimmunocytochemistrycell cultureRNA extractionWestern blottingdata analysis in Rconfocal microscopy
Output against the department
Publications357top 14% of dept.144th of 1,033
this lab
most publishedleast published
Citations13ktop 29% of dept.299th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.