UTHThe University of Texas Health Science Center at Houston · Biochemistry
The Macrophage Insight Lab
Tingting Weng Mills · Houston, Texas
Research Focus
Dr. Tingting Weng Mills' lab at the University of Texas Health Science Center focuses on understanding how macrophages, a type of immune cell, play a role in lung injuries like Acute Respiratory Distress Syndrome (ARDS). They explore the function of a specific protein called NUDT21 that influences RNA processing in these cells, potentially leading to new treatments for ARDS. By studying how NUDT21 is regulated under conditions like low oxygen, the lab aims to find innovative ways to control inflammation and improve patient outcomes.
lung injuryacute respiratory distress syndromemacrophage biologyalternative polyadenylationNUDT21inflammationgene regulationhypoxiacytokines
Research Aims
3AIM 01Demonstrate the functional role of myeloid NUDT21 in murine ARDS models.
AIM 02Determine the mechanisms for NUDT21 repression and assess their potential as therapeutic targets in ARDS.
AIM 03Investigation of the hypoxia/NUDT21/APA axis in human ARDS lungs.
Skills the Lab Values
RNA sequencingmouse modelscell cultureflow cytometryWestern blotbioinformaticsinflammatory assaysgenetic engineeringprotein analysis
Output against the department
Publications98bottom 24% of dept.305th of 402
this lab
most publishedleast published
Citations1.2kbottom 4% of dept.387th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.