Drexel University · PharmacologyDopamine Transporter Regulation Lab
Ole Valente Mortensen · Philadelphia, Pennsylvania
Research Focus
Dr. Ole Valente Mortensen's lab at Drexel University focuses on understanding how dopamine transporters in the brain work, particularly regarding their regulation and modulation. The lab explores novel compounds that target specific sites on these transporters to develop new treatments for mental health disorders, such as ADHD and depression. By studying the mechanisms of these compounds, the lab seeks to identify new therapeutic options for disorders driven by imbalances in neurotransmitter signaling.
dopamine transportersallosteric modulationADHDdepressionpsychostimulantsneurotransmitter regulationligandstherapeutic development
Research Aims
3AIM 01Elucidate mechanisms of allosteric transporter modulation through computational modeling.
AIM 02Evaluate the in vivo utility of compounds affecting dopamine transporters' functions.
AIM 03Employ structure-based design to identify novel A2-specific compounds.
Skills the Lab Values
computational modelingmolecular simulationsbiochemical assaysanimal behavior analysisdrug interaction studiescell culture techniquesWestern blotbehavioral assessmentsin vivo experiments
Output against the department
Publications49bottom 6% of dept.433rd of 462
this lab
most publishedleast published
Citations1.3kbottom 7% of dept.430th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.