University of Pittsburgh-Pittsburgh Campus · Microbiology & ImmunologyJoglekar Lab
Alok Joglekar · Pittsburgh, Pennsylvania
Research Focus
Dr. Alok Joglekar's lab focuses on engineering immune cells to enhance their ability to recognize and respond to disease-causing pathogens and tumors. Through innovative techniques, the lab aims to transform how T cells interact with their targets, potentially leading to new therapies for diseases such as cancer and autoimmune disorders. The research involves developing novel receptor systems that improve the signaling capabilities of T cells, ultimately aiming to revolutionize immune engineering.
T cell engineeringimmunologyMajor Histocompatibility Complex (MHC)cell therapysynthetic immunologyautoimmunitycancer researchsignal transductionadaptive immunity
Research Aims
5AIM 01Develop engineered T cells with enhanced recognition capabilities for disease targets.
AIM 02Create new immune-engineered tools for modulating T cell responses.
AIM 03Explore the role of Major Histocompatibility Complex molecules in T cell signaling.
AIM 04Investigate the therapeutic potential of modulating T cell interactions in cancer and autoimmune diseases.
AIM 05Establish a platform for cellular engineering to broadly apply in synthetic immunology.
Skills the Lab Values
T cell culturegenetic engineeringcell signaling analysisimmunological assaysflow cytometrymolecular cloningantigen presentation techniquesbiological modelingcellular therapy methodologies
Output against the department
Publications48bottom 10% of dept.435th of 486
this lab
most publishedleast published
Citations2.2kbottom 14% of dept.419th of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.