University of California-San Diego · ChemistryTranscription Factor Dynamics Lab
Elizabeth A. Komives · La Jolla, California
Research Focus
Professor Elizabeth A. Komives's lab at UC San Diego focuses on understanding how transcription factors, specifically the nuclear factor kappa B (NFB), interact with DNA to control gene expression crucial for growth and immune responses. The lab uses a combination of theoretical modeling and experimental techniques to explore how these transcription factors assemble into complexes that regulate various biological processes, particularly under stress conditions. Their research has implications for diseases such as cancer, asthma, and autoimmune disorders.
transcription factorsNFBgene expressionDNA-bindingnucleosomes
Research Aims
3AIM 01Determine the role of DNA context in NFB binding to influence transcription activation.
AIM 02Explore how NFB invades nucleosomal DNA and affects its stability.
AIM 03Investigate the interactions between NFB, DNA, and the co-activator RPS3 to form higher-order complexes.
Skills the Lab Values
molecular biophysicsatomic force microscopyNMR spectroscopycomputational modelingprotein complex analysis
Output against the department
Publications319top 35% of dept.76th of 216
this lab
most publishedleast published
Citations10ktop 48% of dept.104th of 216
this lab
most citedleast cited
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