University of Michigan-Ann Arbor · NeuroscienceCognitive Resilience Research Unit
Catherine Cook Kaczorowski · Ann Arbor, Michigan
Research Focus
Dr. Catherine Cook Kaczorowski's research lab at the University of Michigan focuses on understanding the genetic factors that influence cognitive aging and Alzheimer's disease (AD). The team studies how genetic and environmental factors, including sleep and diet, impact brain function and resilience to cognitive decline. By using advanced mouse models and comparing findings to human datasets, the lab aims to identify potential therapeutic targets to improve quality of life for those affected by Alzheimer's disease and cognitive impairments.
Alzheimer's diseasecognitive agingsleep losscaloric restrictiongeneticsmouse modelssex differencesresilienceneuropathology
Research Aims
4AIM 01Identify genetic factors associated with sleep loss in Alzheimer's disease mouse models.
AIM 02Investigate how caloric restriction impacts cognitive outcomes and identify protective genetic mechanisms.
AIM 03Explore sex-specific genetic drivers of Alzheimer's disease symptoms and treatment responses.
AIM 04Validate genetic targets for cognitive resilience through mouse-human translational research.
Skills the Lab Values
mouse modelsgenetic analysisimmunohistochemistryRNA sequencingCrispr gene editingbehavioral assaysbioinformaticsmulti-omics analysisdata integration
Output against the department
Publications148top 49% of dept.330th of 671
this lab
most publishedleast published
Citations2.9kbottom 20% of dept.538th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.