New York Medical College · PharmacologyGupte Lab
Sachin A Gupte · Valhalla, New York
Research Focus
Dr. Sachin A. Gupte's research lab focuses on understanding how metabolic changes, particularly involving a protein called glucose-6-phosphate dehydrogenase (G6PD), can influence vascular diseases. By studying how different forms of G6PD might affect blood vessel cells, the lab aims to uncover new mechanisms that could lead to better treatments for conditions like heart disease and artery stiffness, which are significant health issues worldwide.
vascular diseasesglucose-6-phosphate dehydrogenasevascular smooth muscle cellsepigeneticscardiovascular healthmetabolic syndromepathogenic remodelingredox signalinggene transcription
Research Aims
3AIM 01Investigate how G6PD affects the activity of epigenetic modifiers in vascular smooth muscle cells.
AIM 02Determine the impact of loss-of-function G6PD variants on gene transcription and vascular cell properties.
AIM 03Explore the differences in vascular remodeling and stiffness between G6PD variant rats and wild-type rats under high-fat diet conditions.
Skills the Lab Values
PCRcell cultureanimal models (rats)epigenetic analysisDNA methylation assaysWestern blotATAC-seqFAIRE sequencingflow cytometryhistone modification analysis
Output against the department
Publications187top 47% of dept.218th of 462
this lab
most publishedleast published
Citations4.8kbottom 36% of dept.296th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.