University of Pennsylvania · PharmacologyParhiz Nanotechnology Lab
Hamideh Parhiz · Philadelphia, Pennsylvania
Research Focus
Dr. Hamideh Parhiz's lab focuses on developing innovative nanotechnology to improve drug delivery for treating acute respiratory distress syndrome (ARDS). Through the use of lipid nanoparticles that can deliver modified mRNA, the lab aims to target specific lung cells to enhance therapeutic outcomes. Their research is particularly relevant given the rising incidence of ARDS and aims to provide new treatment avenues to reduce mortality rates.
mRNAlipid nanoparticlesdrug deliveryacute respiratory distress syndromenanotechnologytherapeutic proteinsalveolar targetinginflammationleukocyte infiltration
Research Aims
5AIM 01Develop lipid nanoparticles to deliver modified mRNA specifically to lung cells
AIM 02Target alveolar endothelial cells to reduce capillary leak
AIM 03Target alveolar marginated leukocytes to mitigate inflammatory responses
AIM 04Test the therapeutic efficacy in mouse models of ARDS
AIM 05Evaluate the platform technology for broader applications in lung diseases.
Skills the Lab Values
lipid nanoparticle formulationmRNA synthesisanimal modelscell culture techniquesflow cytometrydrug delivery systemsin vivo imagingimmunohistochemistrybioinformaticsRNA sequencing
Output against the department
Publications62bottom 11% of dept.410th of 462
this lab
most publishedleast published
Citations6.0kbottom 42% of dept.266th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.