University of Vermont · BiologyBotten Lab
Jason W. Botten · Burlington, Vermont
Research Focus
Dr. Jason W. Botten's lab at the University of Vermont focuses on understanding how certain viruses, specifically arenaviruses, produce defective particles that can influence both viral infection and host health. The lab investigates the cellular mechanisms that regulate these defective particles and their role in viral persistence within animal hosts, particularly rodents. By exploring these interactions, the research could provide insights into how zoonotic viruses impact public health.
arenavirusesdefective interfering particlesviral pathogenesispost-translational modificationsrodent reservoirsmolecular biologyzoonotic diseases
Research Aims
5AIM 01Identify the cellular mechanisms regulating the production of defective interfering particles in arenaviruses.
AIM 02Investigate the post-translational modifications that influence viral particle formation.
AIM 03Model the impact of defective particles on host fitness in rodent reservoirs.
AIM 04Explore the implications of these findings for understanding zoonotic virus persistence.
AIM 05Develop innovative tools to manipulate defective particle levels in experimental systems.
Skills the Lab Values
reverse geneticscell culturemolecular cloningprotein purificationanimal modelsWestern blottingmass spectrometryCRISPRfluorescence microscopy
Output against the department
Publications79bottom 23% of dept.794th of 1,033
this lab
most publishedleast published
Citations3.3kbottom 25% of dept.779th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.