Yale University · PharmacologyFerguson Membrane Lab
Kathryn M Ferguson · New Haven, Connecticut
Research Focus
Dr. Kathryn M Ferguson's lab at Yale University focuses on understanding how the environment of cells, specifically the membranes they are part of, affects the behavior and structure of integral membrane proteins (IMPs). This research is critical because many drugs target these proteins, but we often don't fully understand how they work. By using innovative technologies and interdisciplinary collaboration, the lab aims to reveal how these proteins function and interact with their surrounding membranes.
membrane proteinsstructural biologylipidomicsmass spectrometrycryo-electron microscopyGPCRscell signalingbiophysics
Research Aims
3AIM 01Identify the native environments of integral membrane proteins using advanced extraction techniques.
AIM 02Understand how membrane composition influences the function and regulation of membrane proteins.
AIM 03Determine precise structures of membrane proteins and their complexes in native environments.
Skills the Lab Values
cryogenic electron microscopy (cryoEM)lipidomicsnative mass spectrometrybiochemistry techniquescellular signaling assaysoptical imagingproteomicslimited proteolysishydrogen/deuterium exchangemolecular biology
Output against the department
Publications115bottom 32% of dept.314th of 462
this lab
most publishedleast published
Citations13ktop 30% of dept.140th of 462
this lab
most citedleast cited
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