Massachusetts Institute of Technology · EngineeringSynthetic Biology for Cancer and Organoid Solutions
Ron Weiss · Cambridge, Massachusetts
Research Focus
Ron Weiss's lab focuses on using synthetic biology to develop innovative therapeutic approaches for cancer treatment and organoid engineering. The lab is particularly interested in creating engineered RNA-based therapies that can enhance the immune response against tumors, as well as genetically programming stem cells to produce pancreatic organoids with controlled cell populations. Their work aims to improve cancer treatments and advance organoid technology for developmental biology studies.
synthetic biologyimmunotherapyRNA therapiespancreatic organoidsorganoid engineeringcancer treatmentcell programmingimmune responsetumor microenvironment
Research Aims
5AIM 01Develop RNA-based therapies to enhance anti-tumor immune responses.
AIM 02Engineer pancreatic organoids with controlled lineage differentiation.
AIM 03Create synthetic gene circuits for cell type-specific protein expression.
AIM 04Test the effectiveness of engineered therapies in mouse cancer models.
AIM 05Investigate developmental biology using advanced organoid systems.
Skills the Lab Values
cell cultureRNA sequencinggenetic engineeringsynthetic circuit designmouse modelsorganoid developmentflow cytometrylipid nanoparticle formulationprogramming genetic circuits
Output against the department
Publications98bottom 21% of dept.219th of 278
this lab
most publishedleast published
Citations78ktop 2% of dept.5th of 278
this lab
most citedleast cited
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