University of Chicago · GeneticsThe Splice Nexus
Jonathan P Staley · Chicago, Illinois
Research Focus
Dr. Jonathan P. Staley's lab focuses on understanding how genetic variations influence gene regulation and splicing in humans. They develop innovative methods to examine RNA splicing and its role in gene expression, aiming to uncover the biological significance of non-canonical splicing events. Their research has implications for understanding genetic contributions to complex traits and diseases.
RNA splicinggene regulationgenetic variationcomplex traitsexpression quantitative trait locinon-canonical splicinggenomicstranscriptome analysispre-mRNA splicing
Research Aims
5AIM 01Develop novel assays to measure both canonical and non-canonical RNA splicing.
AIM 02Investigate the impact of genetic variants on RNA splicing and gene expression.
AIM 03Explore the relationship between splicing mechanisms and human phenotypic variation.
AIM 04Characterize inter-individual differences in RNA splicing processes.
AIM 05Enhance our understanding of gene regulatory mechanisms and their implications for disease.
Skills the Lab Values
RNA sequencinggenome-wide assay developmentcell line culturebioinformaticsquantitative trait locus mappingdata analysis in geneticsNorthern blottingtranscription profilinganalytical method development
Output against the department
Publications66bottom 16% of dept.218th of 259
this lab
most publishedleast published
Citations5.0kbottom 28% of dept.186th of 259
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.