WMUWestern Michigan University Homer Stryker M.D. School of Medicine · Microbiology & Immunology
Yoshimoto Immunology Lab
Momoko Yoshimoto · Kalamazoo, Michigan
Research Focus
Dr. Momoko Yoshimoto's research focuses on understanding how different types of B cells develop from various origins during fetal development and their significance in health and disease. Her lab explores the developmental pathways of B cells that arise independently of hematopoietic stem cells, which challenges traditional views in immunology. By using advanced mouse models, the lab aims to uncover the functional differences between these newly identified B cell subsets and their counterparts derived from the bone marrow.
B cell developmentHematopoietic stem cellsFetal immunityImmunologyInnate immune cellsB cell subsetsLineage tracingMouse modelsAntibody response
Research Aims
5AIM 01Determine functional differences of B-cells based on their origins.
AIM 02Establish a revised map of B-cell development from embryo to adult.
AIM 03Investigate antibody and cytokine secretion in B-cell subsets.
AIM 04Examine in vivo responses to pneumonia infection.
AIM 05Explore clonal relationships between HSC-derived and fetal-derived B-progenitors.
Skills the Lab Values
Lineage tracingIn vivo barcodingMouse modelsFlow cytometryscRNA sequencingCell cultureSpleen immunologyAntibody assaysPathogen response studies
Output against the department
Publications129bottom 49% of dept.247th of 486
this lab
most publishedleast published
Citations5.9kbottom 44% of dept.272nd of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.