Columbia University in the City of New York · PhysiologySF3B1 and Hematopoiesis Lab
Sergei Doulatov · New York, New York
Research Focus
Dr. Sergei Doulatov's lab focuses on understanding how mutations in the SF3B1 gene affect hematopoietic stem cells, which are crucial for blood production. By exploring how these mutations alter RNA splicing, the lab aims to uncover their role in diseases like myelodysplastic syndromes (MDS). Ultimately, the research seeks to develop new treatment strategies targeting these mutations to improve patient outcomes.
SF3B1 mutationshematopoietic stem cellsmyelodysplastic syndromesRNA splicinggene editing
Research Aims
3AIM 01Define the molecular consequences of SF3B1 mutations on RNA splicing in human hematopoietic stem cells.
AIM 02Explore the mechanisms of clonal expansion and aberrant differentiation in SF3B1-mutated stem cells.
AIM 03Identify therapeutic vulnerabilities in SF3B1-mutant hematopoietic stem cells.
Skills the Lab Values
RNA sequencinggene editingcell culturemouse modelsflow cytometry
Output against the department
Publications130bottom 42% of dept.166th of 286
this lab
most publishedleast published
Citations7.9ktop 42% of dept.119th of 286
this lab
most citedleast cited
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