Massachusetts Institute of Technology · EngineeringBathe Vaccine Lab
Mark Bathe · Cambridge, Massachusetts
Research Focus
Dr. Mark Bathe's lab at MIT focuses on creating innovative vaccine platforms using synthetic DNA-based structures. Their research aims to improve how our immune system responds to serious viruses like HIV and influenza by optimizing the presentation of viral proteins. The lab seeks to understand how different properties of these DNA-based viral particles can harness immune responses to generate long-lasting immunity.
synthetic DNAviral particlesHIVinfluenzavaccine developmentantigen presentationhumoral immunityparticle engineeringimmunogen optimization
Research Aims
5AIM 01Investigate the use of DNA-based viral particles for targeted antigen presentation.
AIM 02Optimize immunogen design to enhance immune response against HIV.
AIM 03Explore antibody responses triggered by different nanoparticle structures.
AIM 04Assess the effectiveness of sequential antigen introduction in vaccine efficacy.
AIM 05Develop a vaccine platform that can be adapted against multiple pathogens.
Skills the Lab Values
DNA manipulationnanoparticle formulationimmunology techniquescell cultureB-cell assaysanimal modelsantibody characterizationflow cytometrymicroscopy
Output against the department
Publications214top 44% of dept.123rd of 278
this lab
most publishedleast published
Citations8.8ktop 42% of dept.116th of 278
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.