Columbia University in the City of New York · BiochemistryMann Lab
Richard S Mann · New York, New York
Research Focus
The Mann lab at Columbia University studies how certain genes, known as Hox genes, control the identities of different body parts in fruit flies, which helps us understand how animals develop. They combine techniques from genetics, biochemistry, and genomics to decipher the roles of these genes at a very detailed level. Through this research, they also explore the mechanisms that could be relevant to human diseases caused by gene regulation issues, like cancer and diabetes.
Hox genesDrosophilagene regulationtranscription factorsdevelopmental biologyDNA bindinganimal developmentmotor neuronsbiochemical techniquesgenomics
Research Aims
5AIM 01Investigate how Hox genes establish body part identities during development.
AIM 02Explore the collaborative interactions between transcription factors and signaling pathways.
AIM 03Decipher the mechanisms of DNA binding specificity among homeodomain proteins.
AIM 04Use innovative techniques to analyze gene regulation in living organisms.
AIM 05Study the identity acquisition of motor neurons for coordinated movement.
Skills the Lab Values
genetic manipulation in Drosophilabiochemical assayshigh-throughput screeningprotein-DNA interaction studiesin vivo analysisgenomic analysisdata interpretationmolecular cloningimmunostainingmicroscopy
Output against the department
Publications222top 36% of dept.143rd of 402
this lab
most publishedleast published
Citations21ktop 19% of dept.77th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.