University of Missouri-Columbia · PharmacologyCalcium Signaling and Lymphatic Function Laboratory
Scott D. Zawieja · Columbia, Missouri
Research Focus
Dr. Scott D. Zawieja's lab investigates how calcium signaling affects the function of lymphatic muscle cells, which are crucial for fluid transport in the body. They study a condition called lymphedema, where these cells fail to work properly, causing painful swelling. By understanding the mechanisms behind calcium handling, the lab aims to discover new treatments and improve patient outcomes for those suffering from lymphedema and related issues.
calcium signalinglymphedemalymphatic muscle cellsstore operated calcium entryfluid homeostasis
Research Aims
3AIM 01Assess the formation of junctions involved in store operated calcium entry in lymphatic muscle cells.
AIM 02Determine how store operated calcium entry influences the contractility of lymphatic muscle cells under pressure.
AIM 03Investigate how calcium oscillations affect gene expression in lymphatic muscle cells.
Skills the Lab Values
cell cultureelectrophysiologycalcium imagingWestern blotreverse transcription PCRmyographyimmunofluorescencemicroscopymouse modelsdata analysis
Output against the department
Publications79bottom 18% of dept.379th of 462
this lab
most publishedleast published
Citations1.9kbottom 12% of dept.406th of 462
this lab
most citedleast cited
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