Washington University in St Louis · NeuroscienceNeurogenetics and Epigenetics Lab
Harrison W Gabel · Saint Louis, Missouri
Research Focus
Dr. Harrison Gabel's lab at Washington University focuses on understanding the role of specific gene mutations in autism and neurodevelopmental disorders. They study how these mutations affect a special form of DNA methylation in neurons, which is crucial for proper brain function. Their research aims to uncover the mechanisms of gene regulation in the nervous system and how disruptions can lead to neurological issues.
autism spectrum disorderneurodevelopmental disordersDNA methylationepigeneticsgene regulationneuronal functiontranscriptomicsspatial transcriptomicsH3K36me2DNMT3A mutation
Research Aims
3AIM 01Investigate the mechanisms by which DNMT3A is targeted by H3K36me2 in neurons.
AIM 02Dissect the epigenetic consequences of NSD1 mutations in mouse models of ASD/NDD.
AIM 03Employ spatial transcriptomic technologies to analyze gene dysregulation in various cell types affected by ASD/NDD mutations.
Skills the Lab Values
DNA methylation analysismouse modelsgenetic manipulationWestern blotPCRspatial transcriptomicscell cultureRNA sequencingbioinformaticsimmunohistochemistry
Output against the department
Publications65bottom 17% of dept.555th of 671
this lab
most publishedleast published
Citations6.1kbottom 42% of dept.387th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.