UMUniversity of Maine · Biochemistry
Mycobacterial Resistance and Prophage Dynamics Lab
Sally Molloy · Orono, Maine
Research Focus
Dr. Sally Molloy's lab at the University of Maine focuses on understanding how certain viruses, known as prophages, help mycobacteria resist antibiotics. This research is important because infections caused by drug-resistant mycobacteria present a major public health challenge. By investigating the mechanisms that these prophages use to alter gene expression and enhance bacterial survival, the lab aims to provide insights that could improve treatment options for resistant infections.
mycobacterial resistanceprophageantibiotic resistancetoxinsgene expressionphage therapypathogen interactiondrug resistance
Research Aims
5AIM 01Investigate the role of prophages in mycobacterial antibiotic resistance.
AIM 02Characterize the expression patterns and secretion mechanisms of prophage-encoded toxins.
AIM 03Examine how toxin proteins affect lytic phage infection in mycobacteria.
AIM 04Assess the interaction between prophage toxins and antibiotic resistance genes.
AIM 05Explore potential therapeutic applications stemming from prophage interactions.
Skills the Lab Values
PCRcell cultureWestern blottingfluorescence microscopygenetic transcription analysiscoculture techniquespathogen modelingdata analysis in microbiology
Output against the department
Publications34bottom 3% of dept.390th of 402
this lab
most publishedleast published
Citations784bottom 2% of dept.393rd of 402
this lab
most citedleast cited
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