Cornell University · BiochemistryCellular Aging and Autophagy Lab
Martin Graef · Ithaca, New York
Research Focus
Dr. Martin Graef's lab at Cornell University studies how cellular aging works, particularly through the lens of autophagy, a process where cells clean out damaged components. Using yeast as a model organism, the lab investigates how different forms of autophagy can affect lifespan and aging. The goal is to uncover new biological mechanisms that could help improve health as we age and might one day inform therapies for age-related diseases.
autophagycellular agingmitophagyyeast modelgenome-wide mappinglifespan extensionaging modifiersmitochondrial functionselective autophagy
Research Aims
3AIM 01Deconvolve the functions of autophagy in cellular aging.
AIM 02Identify genetic requirements for mitophagy in replicative aging.
AIM 03Define mechanisms of how mitophagy impacts mitochondrial size and lifespan.
Skills the Lab Values
genetic engineeringcell cultureyeast geneticsPCRWestern blottingRNA sequencingmicroscopybioinformaticsdata miningexperimental design
Output against the department
Publications69bottom 13% of dept.347th of 402
this lab
most publishedleast published
Citations11ktop 46% of dept.184th of 402
this lab
most citedleast cited
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