University of New Hampshire-Main Campus · BiochemistryElsawa Immunology Lab
Sherine F. Elsawa · Durham, New Hampshire
Research Focus
Dr. Sherine F. Elsawa's lab focuses on understanding how a specific protein called GLI2 helps control the production of antibodies by B cells, which are essential for our immune response. The lab uses both special human B cell lines and genetically modified mice to explore how GLI2 affects the transcription of immunoglobulin genes, which are vital in responding to infections and diseases. This research is particularly important for understanding immune disorders where antibody production goes awry, like certain autoimmune diseases and cancers.
antibody productionB cell differentiationGLI2class switch recombinationimmunoglobulin heavy chaintranscriptional regulationimmune disorders
Research Aims
4AIM 01Investigate the role of GLI2 in regulating immunoglobulin heavy chain transcription.
AIM 02Explore how GLI2 influences class switch recombination in B cells.
AIM 03Understand the mechanisms by which GLI2 affects B cell differentiation.
AIM 04Utilize monoclonal IgM-secreting B cell lines to study antibody production.
Skills the Lab Values
cell culturemouse modelsB cell assaysPCRflow cytometryWestern blotRNA extractiongene expression analysis
Output against the department
Publications160bottom 45% of dept.221st of 402
this lab
most publishedleast published
Citations3.3kbottom 16% of dept.339th of 402
this lab
most citedleast cited
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